Experimental 70% Hepatectomy Model: Apoptotic Index, Proliferative Index and Mitotic Index

نویسندگان

چکیده

Liver regeneration is known to begin after experimentally induced liver resection. At first 24-48 hours, DNA synthesis reaches the maximum level resection and significantly occur on 10 days. In this study, we was examined of 1st 14th days 
 experiment 21 Wistar albino male rats were used. The randomly divided into three groups. All groups realized midline incision with laparotomy for liver. Pedicles left lateral median lobes applied 70% hepatectomy by 4/0 silk binding. end days, tissue removed light misroscobic analysis.
 all showed some histopatological changes such as sinuzoidal dilatation, vacuolization in hepatocytes. This findings seem increase at II. grup more than groups.
 Mitotic index, apoptotic index proliferation values group reached level. Other (III) dramatically reduced value these reach near control group. Relative weight that determined each statistically significant differences compared

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ژورنال

عنوان ژورنال: Sakarya University Journal of Science

سال: 2021

ISSN: ['1301-4048', '2147-835X']

DOI: https://doi.org/10.16984/saufenbilder.886245